Palo santo is derived from specific trees found in the South American rain forests of the Galapagos Islands, Ecuador, and Peru, and has been used throughout history for a variety of healing purposes including in medicinal and spiritual cleansing ceremonies involving both individuals and the spaces they inhabit. As with sage, the wood should be ignited then gently blown down to an ember to allow the smoke to spread around the room. Guiding the smoke to different areas of the room including corners, inside closets, and in each direction of the compass is important. Also, be sure to allow the wood to produce enough smoke to fill the air. Regardless of what substance you choose, both sage and palo santo are time-tested, ancient tools for clearing space and releasing negative energy.